Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer

BACKGROUND: Nutrition is believed to be a primary contributor in regulating gene expression by affecting epigenetic pathways such as DNA methylation and histone modification. Resveratrol and pterostilbene are phytoalexins produced by plants as part of their defense system. These two bioactive compou...

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Dettagli Bibliografici
Pubblicato in:BMC Cancer
Autori principali: Kala, Rishabh, Shah, Harsh N., Martin, Samantha L., Tollefsbol, Trygve O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603342/
https://ncbi.nlm.nih.gov/pubmed/26459286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1693-z
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