Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1

INTRODUCTION: BTB and CNC homology 1 (Bach1) is a transcriptional repressor of Heme oxygenase-1 (HO-1), which is cytoprotective through its antioxidant effects. The objective of this study was to define the role of Bach1 in cartilage homeostasis and osteoarthritis (OA) development using in vitro mod...

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Pubblicato in:Arthritis Res Ther
Autori principali: Takada, Tsuyoshi, Miyaki, Shigeru, Ishitobi, Hiroyuki, Hirai, Yuya, Nakasa, Tomoyuki, Igarashi, Kazuhiko, Lotz, Martin K., Ochi, Mitsuo
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603301/
https://ncbi.nlm.nih.gov/pubmed/26458773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0792-1
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