Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease

Down syndrome (DS) is the most common genetic cause of intellectual disability and is primarily caused by the triplication of chromosome 21. The overexpression of APP may be sufficient to overexpression's disease (AD) neuropathology that is observed in virtually all individuals with DS by the a...

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Gepubliceerd in:Neurobiol Aging
Hoofdauteurs: Wilcock, Donna M., Hurban, Jennifer, Helman, Alex M., Sudduth, Tiffany L., McCarty, Katie L., Beckett, Tina L., Ferrell, Joshua C., Murphy, M. Paul, Abner, Erin L., Schmitt, Frederick A., Head, Elizabeth
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4602365/
https://ncbi.nlm.nih.gov/pubmed/26103884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.05.016
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