Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease

Down syndrome (DS) is the most common genetic cause of intellectual disability and is primarily caused by the triplication of chromosome 21. The overexpression of APP may be sufficient to overexpression's disease (AD) neuropathology that is observed in virtually all individuals with DS by the a...

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Publicado en:Neurobiol Aging
Main Authors: Wilcock, Donna M., Hurban, Jennifer, Helman, Alex M., Sudduth, Tiffany L., McCarty, Katie L., Beckett, Tina L., Ferrell, Joshua C., Murphy, M. Paul, Abner, Erin L., Schmitt, Frederick A., Head, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4602365/
https://ncbi.nlm.nih.gov/pubmed/26103884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.05.016
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