Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking: Implications for Atherogenesis Under Oxidative Stress

OBJECTIVE: Oxidative stress associated with cardiovascular disease can produce various oxidized lipids, including cholesterol oxides such as 7-hydroperoxide (7-OOH), 7-hydroxide (7-OH), and 7-ketone (7=O). Unlike 7=O and 7-OH, 7-OOH is redox-active, giving rise to the others via potentially toxic fr...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Korytowski, Witold, Wawak, Katarzyna, Pabisz, Pawel, Schmitt, Jared C., Chadwick, Alexandra C., Sahoo, Daisy, Girotti, Albert W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601804/
https://ncbi.nlm.nih.gov/pubmed/26315403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306210
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