Dasatinib Attenuates Pressure Overload Induced Cardiac Fibrosis in a Murine Transverse Aortic Constriction Model

Reactive cardiac fibrosis resulting from chronic pressure overload (PO) compromises ventricular function and contributes to congestive heart failure. We explored whether nonreceptor tyrosine kinases (NTKs) play a key role in fibrosis by activating cardiac fibroblasts (CFb), and could potentially ser...

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Pubblicato in:PLoS One
Autori principali: Balasubramanian, Sundaravadivel, Pleasant, Dorea L., Kasiganesan, Harinath, Quinones, Lakeya, Zhang, Yuhua, Sundararaj, Kamala P., Roche, Sandra, O’Connor, Robert, Bradshaw, Amy D., Kuppuswamy, Dhandapani
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601773/
https://ncbi.nlm.nih.gov/pubmed/26458186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140273
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