Dasatinib Attenuates Pressure Overload Induced Cardiac Fibrosis in a Murine Transverse Aortic Constriction Model

Reactive cardiac fibrosis resulting from chronic pressure overload (PO) compromises ventricular function and contributes to congestive heart failure. We explored whether nonreceptor tyrosine kinases (NTKs) play a key role in fibrosis by activating cardiac fibroblasts (CFb), and could potentially ser...

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Udgivet i:PLoS One
Main Authors: Balasubramanian, Sundaravadivel, Pleasant, Dorea L., Kasiganesan, Harinath, Quinones, Lakeya, Zhang, Yuhua, Sundararaj, Kamala P., Roche, Sandra, O’Connor, Robert, Bradshaw, Amy D., Kuppuswamy, Dhandapani
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601773/
https://ncbi.nlm.nih.gov/pubmed/26458186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140273
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