Role of genomic instability and p53 in AID-induced c-myc-Igh translocations

Chromosomal translocations involving the immunoglobulin switch region are a hallmark feature of B-cell malignancies(1). However, little is known about the molecular mechanism by which primary B cells acquire or guard against these lesions. Here we find that translocations between c-myc and the IgH l...

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Udgivet i:Nature
Main Authors: Ramiro, Almudena R., Jankovic, Mila, Callen, Elsa, Difilippantonio, Simone, Chen, Hua-Tang, McBride, Kevin M., Eisenreich, Thomas R., Chen, Junjie, Dickins, Ross A., Lowe, Scott W., Nussenzweig, Andre, Nussenzweig, Michel C.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601098/
https://ncbi.nlm.nih.gov/pubmed/16400328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature04495
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