Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue

We report an unexpected link between aging, thermogenesis and weight gain via the orphan G protein-coupled receptor GPR3. Mice lacking GPR3 and maintained on normal chow had similar body weights during their first 5 months of life, but gained considerably more weight thereafter and displayed reduced...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Godlewski, Grzegorz, Jourdan, Tony, Szanda, Gergő, Tam, Joseph, Resat Cinar, Harvey-White, Judith, Liu, Jie, Mukhopadhyay, Bani, Pacher, Pál, Ming Mo, Fong, Osei-Hyiaman, Douglas, George Kunos
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601089/
https://ncbi.nlm.nih.gov/pubmed/26455425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14953
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items