Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia

Neurodegenerative diseases have been linked to inflammation, but whether altered immunomodulation plays a causative role in neurodegeneration is not clear. We show that lack of cytokine interferon-β (IFN-β) signaling causes spontaneous neurodegeneration in the absence of neurodegenerative disease-ca...

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Publicat a:Cell
Autors principals: Ejlerskov, Patrick, Hultberg, Jeanette Göransdotter, Wang, JunYang, Carlsson, Robert, Ambjørn, Malene, Kuss, Martin, Liu, Yawei, Porcu, Giovanna, Kolkova, Kateryna, Friis Rundsten, Carsten, Ruscher, Karsten, Pakkenberg, Bente, Goldmann, Tobias, Loreth, Desiree, Prinz, Marco, Rubinsztein, David C., Issazadeh-Navikas, Shohreh
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601085/
https://ncbi.nlm.nih.gov/pubmed/26451483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.08.069
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