Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia

Neurodegenerative diseases have been linked to inflammation, but whether altered immunomodulation plays a causative role in neurodegeneration is not clear. We show that lack of cytokine interferon-β (IFN-β) signaling causes spontaneous neurodegeneration in the absence of neurodegenerative disease-ca...

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Publicado no:Cell
Main Authors: Ejlerskov, Patrick, Hultberg, Jeanette Göransdotter, Wang, JunYang, Carlsson, Robert, Ambjørn, Malene, Kuss, Martin, Liu, Yawei, Porcu, Giovanna, Kolkova, Kateryna, Friis Rundsten, Carsten, Ruscher, Karsten, Pakkenberg, Bente, Goldmann, Tobias, Loreth, Desiree, Prinz, Marco, Rubinsztein, David C., Issazadeh-Navikas, Shohreh
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601085/
https://ncbi.nlm.nih.gov/pubmed/26451483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.08.069
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