Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance

[Image: see text] Catechol diether compounds have nanomolar antiviral and enzymatic activity against HIV with reverse transcriptase (RT) variants containing K101P, a mutation that confers high-level resistance to FDA-approved non-nucleoside inhibitors efavirenz and rilpivirine. Kinetic data suggests...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Gray, William T., Frey, Kathleen M., Laskey, Sarah B., Mislak, Andrea C., Spasov, Krasimir A., Lee, Won-Gil, Bollini, Mariela, Siliciano, Robert F., Jorgensen, William L., Anderson, Karen S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601059/
https://ncbi.nlm.nih.gov/pubmed/26487915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00254
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