Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries

Broadly neutralizing antibodies developed from the IGHV1–69 germline gene are known to bind to the stem region of hemagglutinin in diverse influenza viruses but the sequence determinants for the antigen recognition, including neutralization potency and binding affinity, are not clearly understood. S...

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Udgivet i:Sci Rep
Main Authors: Tung, Chao-Ping, Chen, Ing-Chien, Yu, Chung-Ming, Peng, Hung-Pin, Jian, Jhih-Wei, Ma, Shiou-Hwa, Lee, Yu-Ching, Jan, Jia-Tsrong, Yang, An-Suei
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601012/
https://ncbi.nlm.nih.gov/pubmed/26456860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15053
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