DDX3Y gene rescue of a Y chromosome AZFa deletion restores germ cell formation and transcriptional programs

Deletions of the AZFa region (AZoospermia Factor-a) region of the human Y chromosome cause irreversible spermatogenic failure that presents clinically in men as Sertoli-cell only (SCO) pathology of the testis. Deletions of the AZFa region typically encompass two genes: DDX3Y and USP9Y. However, huma...

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Udgivet i:Sci Rep
Main Authors: Ramathal, Cyril, Angulo, Benjamin, Sukhwani, Meena, Cui, Jun, Durruthy-Durruthy, Jens, Fang, Fang, Schanes, Paula, Turek, Paul J., Orwig, Kyle E., Reijo Pera, Renee
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601010/
https://ncbi.nlm.nih.gov/pubmed/26456624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15041
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