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DDX3Y gene rescue of a Y chromosome AZFa deletion restores germ cell formation and transcriptional programs
Deletions of the AZFa region (AZoospermia Factor-a) region of the human Y chromosome cause irreversible spermatogenic failure that presents clinically in men as Sertoli-cell only (SCO) pathology of the testis. Deletions of the AZFa region typically encompass two genes: DDX3Y and USP9Y. However, huma...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4601010/ https://ncbi.nlm.nih.gov/pubmed/26456624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15041 |
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