The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice

Muscle- and liver-derived IGF-1 play important roles in muscle anabolism throughout growth and aging. Yet, prolonged food restriction is thought to increase longevity in part by lowering levels of IGF-1, which in turn reduces the risk for developing various cancers. The dietary factors that modulate...

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Pubblicato in:Exp Gerontol
Autori principali: Hamrick, M.W., Dukes, A., Arounleut, P., Davis, C., Periyasamy-Thandavan, S., Mork, S., Herberg, S., Johnson, M.H., Isales, C.M., Hill, W.D., Otvos, L., de Chantemèle, E.J. Belin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600673/
https://ncbi.nlm.nih.gov/pubmed/26220769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2015.07.014
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