Genetic deletion and pharmacological inhibition of Akt1 isoform attenuates bladder cancer cell proliferation, motility and invasion

Isoform specific expression, intracellular localization and function of Akt in bladder cancer are not known. In the current study, we identified Akt1, followed by Akt2 and Akt3 as the predominant Akt isoform in human T24 and UN-UC-3 metastatic bladder cancer cells. Whereas Akt1 is localized at the m...

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Detalhes bibliográficos
Publicado no:Eur J Pharmacol
Main Authors: Sabbineni, Harika, Alwhaibi, Abdulrahman, Goc, Anna, Gao, Fei, Pruitt, Alanna, Somanath, Payaningal R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600438/
https://ncbi.nlm.nih.gov/pubmed/26148825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2015.06.059
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