Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

Ikaros (IKZF1) is a tumor suppressor that binds DNA and regulates expression of its target genes. The mechanism of Ikaros activity as a tumor suppressor and the regulation of Ikaros function in leukemia are unknown. Here, we demonstrate that Ikaros controls cellular proliferation by repressing expre...

詳細記述

保存先:
書誌詳細
出版年:Blood
主要な著者: Song, Chunhua, Gowda, Chandrika, Pan, Xiaokang, Ding, Yali, Tong, Yongqing, Tan, Bi-Hua, Wang, Haijun, Muthusami, Sunil, Ge, Zheng, Sachdev, Mansi, Amin, Shantu G., Desai, Dhimant, Gowda, Krishne, Gowda, Raghavendra, Robertson, Gavin P., Schjerven, Hilde, Muschen, Markus, Payne, Kimberly J., Dovat, Sinisa
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2015
主題:
Lymphoid Neoplasia
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600018/
https://ncbi.nlm.nih.gov/pubmed/26219304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-651505
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