Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia

Impaired function of the Ikaros (IKZF1) protein is associated with the development of high-risk B-cell precursor acute lymphoblastic leukemia (B-ALL). The mechanisms of Ikaros tumor suppressor activity in leukemia are unknown. Ikaros binds to the upstream regulatory elements of its target genes and...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wang, Haijun, Song, Chunhua, Ding, Yali, Pan, Xiaokang, Ge, Zheng, Tan, Bi-Hua, Gowda, Chandrika, Sachdev, Mansi, Muthusami, Sunil, Ouyang, Hongsheng, Lai, Liangxue, Francis, Olivia L., Morris, Christopher L., Abdel-Azim, Hisham, Dorsam, Glenn, Xiang, Meixian, Payne, Kimberly J., Dovat, Sinisa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759178/
https://ncbi.nlm.nih.gov/pubmed/26655717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679332
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