Significance of PIK3CA Mutations in Patients with Early Breast Cancer Treated with Adjuvant Chemotherapy: A Hellenic Cooperative Oncology Group (HeCOG) Study

BACKGROUND: The PI3K-AKT pathway is frequently activated in breast cancer. PIK3CA mutations are most frequently found in the helical (exon 9) and kinase (exon 20) domains of this protein. The aim of the present study was to examine the role of different types of PIK3CA mutations in combination with...

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Vydáno v:PLoS One
Hlavní autoři: Papaxoinis, George, Kotoula, Vassiliki, Alexopoulou, Zoi, Kalogeras, Konstantine T., Zagouri, Flora, Timotheadou, Eleni, Gogas, Helen, Pentheroudakis, George, Christodoulou, Christos, Koutras, Angelos, Bafaloukos, Dimitrios, Aravantinos, Gerasimos, Papakostas, Pavlos, Charalambous, Elpida, Papadopoulou, Kyriaki, Varthalitis, Ioannis, Efstratiou, Ioannis, Zaramboukas, Thomas, Patsea, Helen, Scopa, Chrisoula D., Skondra, Maria, Kosmidis, Paris, Pectasides, Dimitrios, Fountzilas, George
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599795/
https://ncbi.nlm.nih.gov/pubmed/26452060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140293
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