Significance of PIK3CA Mutations in Patients with Early Breast Cancer Treated with Adjuvant Chemotherapy: A Hellenic Cooperative Oncology Group (HeCOG) Study

BACKGROUND: The PI3K-AKT pathway is frequently activated in breast cancer. PIK3CA mutations are most frequently found in the helical (exon 9) and kinase (exon 20) domains of this protein. The aim of the present study was to examine the role of different types of PIK3CA mutations in combination with...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:PLoS One
المؤلفون الرئيسيون: Papaxoinis, George, Kotoula, Vassiliki, Alexopoulou, Zoi, Kalogeras, Konstantine T., Zagouri, Flora, Timotheadou, Eleni, Gogas, Helen, Pentheroudakis, George, Christodoulou, Christos, Koutras, Angelos, Bafaloukos, Dimitrios, Aravantinos, Gerasimos, Papakostas, Pavlos, Charalambous, Elpida, Papadopoulou, Kyriaki, Varthalitis, Ioannis, Efstratiou, Ioannis, Zaramboukas, Thomas, Patsea, Helen, Scopa, Chrisoula D., Skondra, Maria, Kosmidis, Paris, Pectasides, Dimitrios, Fountzilas, George
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2015
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599795/
https://ncbi.nlm.nih.gov/pubmed/26452060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140293
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