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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitt’s lymphoma uncouple proliferation from apoptosis and, as a res...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nature
Egile Nagusiak: Hemann, Michael T., Bric, Anka, Teruya-Feldstein, Julie, Herbst, Andreas, Nilsson, Jonas A., Cordon-Cardo, Carlos, Cleveland, John L., Tansey, William P., Lowe, Scott W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2005
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599579/
https://ncbi.nlm.nih.gov/pubmed/16094360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature03845
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