Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitt’s lymphoma uncouple proliferation from apoptosis and, as a res...

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Publicado en:Nature
Main Authors: Hemann, Michael T., Bric, Anka, Teruya-Feldstein, Julie, Herbst, Andreas, Nilsson, Jonas A., Cordon-Cardo, Carlos, Cleveland, John L., Tansey, William P., Lowe, Scott W.
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599579/
https://ncbi.nlm.nih.gov/pubmed/16094360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature03845
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