Increased Heme Levels in the Heart Lead to Exacerbated Ischemic Injury

BACKGROUND: Heme is an essential iron-containing molecule for cardiovascular physiology, but in excess it may increase oxidative stress. Failing human hearts have increased heme levels, with upregulation of the rate-limiting enzyme in heme synthesis, δ-aminolevulinic acid synthase 2 (ALAS2), which i...

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Bibliographic Details
Published in:	J Am Heart Assoc
Main Authors:	Sawicki, Konrad Teodor, Shang, Meng, Wu, Rongxue, Chang, Hsiang-Chun, Khechaduri, Arineh, Sato, Tatsuya, Kamide, Christine, Liu, Ting, Naga Prasad, Sathyamangla V, Ardehali, Hossein
Format:	Artigo
Language:	Inglês
Published:	John Wiley & Sons, Ltd 2015
Subjects:	Original Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4599478/ https://ncbi.nlm.nih.gov/pubmed/26231844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002272
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Increased Heme Levels in the Heart Lead to Exacerbated Ischemic Injury

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