Addition of rapamycin and hydroxychloroquine to metronomic chemotherapy as a second line treatment results in high salvage rates for refractory metastatic solid tumors: a pilot safety and effectiveness analysis in a small patient cohort

BACKGROUND: Autophagy is an important oncotarget that can be modulated during anti-cancer therapy. Enhancing autophagy using chemotherapy and rapamycin (Rapa) treatment and then inhibiting it using hydroxychloroquine (HCQ) could synergistically improve therapy outcome in cancer patients. It is still...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Chi, Kwan-Hwa, Ko, Hui-Ling, Yang, Kai-Lin, Lee, Cheng-Yen, Chi, Mau-Shin, Kao, Shang-Jyh
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Clinical Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599303/
https://ncbi.nlm.nih.gov/pubmed/25944689
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