Addition of rapamycin and hydroxychloroquine to metronomic chemotherapy as a second line treatment results in high salvage rates for refractory metastatic solid tumors: a pilot safety and effectiveness analysis in a small patient cohort

BACKGROUND: Autophagy is an important oncotarget that can be modulated during anti-cancer therapy. Enhancing autophagy using chemotherapy and rapamycin (Rapa) treatment and then inhibiting it using hydroxychloroquine (HCQ) could synergistically improve therapy outcome in cancer patients. It is still...

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Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Chi, Kwan-Hwa, Ko, Hui-Ling, Yang, Kai-Lin, Lee, Cheng-Yen, Chi, Mau-Shin, Kao, Shang-Jyh
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Clinical Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599303/
https://ncbi.nlm.nih.gov/pubmed/25944689
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