Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL

In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL cells and is associated with decreased levels...

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Vydáno v:Oncotarget
Hlavní autoři: De Falco, Filomena, Sabatini, Rita, Del Papa, Beatrice, Falzetti, Franca, Di Ianni, Mauro, Sportoletti, Paolo, Baldoni, Stefano, Screpanti, Isabella, Marconi, Pierfrancesco, Rosati, Emanuela
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599289/
https://ncbi.nlm.nih.gov/pubmed/26041884
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