Vitamin D(3)-dependent VDR signaling delays ron-mediated breast tumorigenesis through suppression of β-catenin activity

The Ron receptor is upregulated in human breast cancers and correlates with enhanced metastasis and reduced patient survival. Ron overexpression drives mammary tumorigenesis through direct β-catenin activation and augmented tumor cell proliferation, migration and invasion. Ron and β-catenin are also...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Johnson, Abby L., Zinser, Glendon M., Waltz, Susan E.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599271/
https://ncbi.nlm.nih.gov/pubmed/26008979
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