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Vitamin D(3)-dependent VDR signaling delays ron-mediated breast tumorigenesis through suppression of β-catenin activity
The Ron receptor is upregulated in human breast cancers and correlates with enhanced metastasis and reduced patient survival. Ron overexpression drives mammary tumorigenesis through direct β-catenin activation and augmented tumor cell proliferation, migration and invasion. Ron and β-catenin are also...
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| Publié dans: | Oncotarget |
|---|---|
| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Impact Journals LLC
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4599271/ https://ncbi.nlm.nih.gov/pubmed/26008979 |
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