Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDA) harbors an exceedingly poor prognosis, and is generally considered a therapy-recalcitrant disease due to poor response to conventional chemotherapy coupled with non-actionable genetic drivers (e.g. KRAS mutations). However, PDA frequently loses p16ink4a, thereb...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Witkiewicz, Agnieszka K., Borja, Nicholas A., Franco, Jorge, Brody, Jonathan R., Yeo, Charles J., Mansour, John, Choti, Michael A., McCue, Peter, Knudsen, Erik S.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2015
Teme:
Priority Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599237/
https://ncbi.nlm.nih.gov/pubmed/26158861
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