Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDA) harbors an exceedingly poor prognosis, and is generally considered a therapy-recalcitrant disease due to poor response to conventional chemotherapy coupled with non-actionable genetic drivers (e.g. KRAS mutations). However, PDA frequently loses p16ink4a, thereb...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Witkiewicz, Agnieszka K., Borja, Nicholas A., Franco, Jorge, Brody, Jonathan R., Yeo, Charles J., Mansour, John, Choti, Michael A., McCue, Peter, Knudsen, Erik S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599237/
https://ncbi.nlm.nih.gov/pubmed/26158861
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