Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation

Why mammalian cells possess multiple DNA glycosylases (DGs) with overlapping substrate ranges for repairing oxidatively damaged bases via the base excision repair (BER) pathway is a long-standing question. To determine the biological role of these DGs, null animal models have been generated. Here, w...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Biol Chem
Κύριοι συγγραφείς: Chakraborty, Anirban, Wakamiya, Maki, Venkova-Canova, Tatiana, Pandita, Raj K., Aguilera-Aguirre, Leopoldo, Sarker, Altaf H., Singh, Dharmendra Kumar, Hosoki, Koa, Wood, Thomas G., Sharma, Gulshan, Cardenas, Victor, Sarkar, Partha S., Sur, Sanjiv, Pandita, Tej K., Boldogh, Istvan, Hazra, Tapas K.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2015
Θέματα:
DNA and Chromosomes
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598976/
https://ncbi.nlm.nih.gov/pubmed/26245904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.658146
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