Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation

Why mammalian cells possess multiple DNA glycosylases (DGs) with overlapping substrate ranges for repairing oxidatively damaged bases via the base excision repair (BER) pathway is a long-standing question. To determine the biological role of these DGs, null animal models have been generated. Here, w...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chakraborty, Anirban, Wakamiya, Maki, Venkova-Canova, Tatiana, Pandita, Raj K., Aguilera-Aguirre, Leopoldo, Sarker, Altaf H., Singh, Dharmendra Kumar, Hosoki, Koa, Wood, Thomas G., Sharma, Gulshan, Cardenas, Victor, Sarkar, Partha S., Sur, Sanjiv, Pandita, Tej K., Boldogh, Istvan, Hazra, Tapas K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598976/
https://ncbi.nlm.nih.gov/pubmed/26245904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.658146
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