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Excision release of 5-hydroxycytosine oxidatively induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation
BACKGROUND: Ragweed pollen extract (RWPE) induces TLR4-NFicB-CXCL-dependent recruitment of ROS-generating neutrophils to the airway and OGG1 DNA glycosy-lase-dependent excision of oxidatively induced 8-OH-Gua DNA base lesions from the airway epithelial cell genome. Administration of free 8-OH-Gua ba...
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| Publicado no: | Clin Exp Allergy |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6588164/ https://ncbi.nlm.nih.gov/pubmed/30244512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cea.13284 |
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