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Synthesis of diverse β-quaternary ketones via palladium-catalyzed asymmetric conjugate addition of arylboronic acids to cyclic enones

The development and optimization of a palladium-catalyzed asymmetric conjugate addition of arylboronic acids to cyclic enone conjugate acceptors is described. These reactions employ air-stable and readily-available reagents in an operationally simple and robust transformation that yields β-quaternar...

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Detalhes bibliográficos
Publicado no:Tetrahedron
Main Authors: Holder, Jeffrey C., Goodman, Emmett D., Kikushima, Kotaro, Gatti, Michele, Marziale, Alexander N., Stoltz, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598955/
https://ncbi.nlm.nih.gov/pubmed/26461082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2014.11.048
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