GDF-15 Secreted from Human Umbilical Cord Blood Mesenchymal Stem Cells Delivered Through the Cerebrospinal Fluid Promotes Hippocampal Neurogenesis and Synaptic Activity in an Alzheimer's Disease Model

Our previous studies demonstrated that transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) into the hippocampus of a transgenic mouse model of Alzheimer's disease (AD) reduced amyloid-β (Aβ) plaques and enhanced cognitive function through paracrine action. D...

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Dades bibliogràfiques
Publicat a:Stem Cells Dev
Autors principals: Kim, Dong Hyun, Lee, Dahm, Chang, Eun Hyuk, Kim, Ji Hyun, Hwang, Jung Won, Kim, Ju-Yeon, Kyung, Jae Won, Kim, Sung Hyun, Oh, Jeong Su, Shim, Sang Mi, Na, Duk Lyul, Oh, Wonil, Chang, Jong Wook
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2015
Matèries:
Original Research Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598918/
https://ncbi.nlm.nih.gov/pubmed/26154268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2014.0487
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