Thrombospondin-1 secreted by human umbilical cord blood-derived mesenchymal stem cells rescues neurons from synaptic dysfunction in Alzheimer’s disease model

Alzheimer’s disease (AD) is an incurable neurodegenerative disease characterised clinically by learning and memory impairments. Amyloid beta (Aβ) peptide-induced synaptic dysfunction is a pathological process associated with early-stage AD. Here, we show that paracrine action of human umbilical cord...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kim, Dong Hyun, Lim, Hoon, Lee, Dahm, Choi, Soo Jin, Oh, Wonil, Yang, Yoon Sun, Oh, Jeong Su, Hwang, Hyun Ho, Jeon, Hong Bae
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762817/
https://ncbi.nlm.nih.gov/pubmed/29321508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18542-0
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