BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5

The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in breast cancer cells, KLF5 is stabilized by the deubiquitinase (DUB) BAP1. With a genome-wide siRNA library screen...

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Vydáno v:Nat Commun
Hlavní autoři: Qin, Junying, Zhou, Zhongmei, Chen, Wenlin, Wang, Chunyan, Zhang, Hailin, Ge, Guangzhe, Shao, Ming, You, Dingyun, Fan, Zhixiang, Xia, Houjun, Liu, Rong, Chen, Ceshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598844/
https://ncbi.nlm.nih.gov/pubmed/26419610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9471
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