Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation

Out of the breast cancer subtypes, triple-negative breast cancer (TNBC) has the poorest prognosis without effective targeted therapies. Metformin, a first-line drug for type 2 diabetes mellitus, was demonstrated to target breast cancer stem cells selectively. However, the efficiency and the mechanis...

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Pubblicato in:Cell Discov
Autori principali: Shi, Peiguo, Liu, Wenjing, Tala, Wang, Haixia, Li, Fubing, Zhang, Hailin, Wu, Yingying, Kong, Yanjie, Zhou, Zhongmei, Wang, Chunyan, Chen, Wenlin, Liu, Rong, Chen, Ceshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396048/
https://ncbi.nlm.nih.gov/pubmed/28480051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2017.10
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