Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation

Out of the breast cancer subtypes, triple-negative breast cancer (TNBC) has the poorest prognosis without effective targeted therapies. Metformin, a first-line drug for type 2 diabetes mellitus, was demonstrated to target breast cancer stem cells selectively. However, the efficiency and the mechanis...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Shi, Peiguo, Liu, Wenjing, Tala, Wang, Haixia, Li, Fubing, Zhang, Hailin, Wu, Yingying, Kong, Yanjie, Zhou, Zhongmei, Wang, Chunyan, Chen, Wenlin, Liu, Rong, Chen, Ceshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396048/
https://ncbi.nlm.nih.gov/pubmed/28480051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2017.10
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados