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BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5
The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in breast cancer cells, KLF5 is stabilized by the deubiquitinase (DUB) BAP1. With a genome-wide siRNA library screen...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4598844/ https://ncbi.nlm.nih.gov/pubmed/26419610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9471 |
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