Discovery of Novel Anti-prion Compounds Using In Silico and In Vitro Approaches

Prion diseases are associated with the conformational conversion of the physiological form of cellular prion protein (PrP(C)) to the pathogenic form, PrP(Sc). Compounds that inhibit this process by blocking conversion to the PrP(Sc) could provide useful anti-prion therapies. However, no suitable dru...

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Publicado no:Sci Rep
Main Authors: Hyeon, Jae Wook, Choi, Jiwon, Kim, Su Yeon, Govindaraj, Rajiv Gandhi, Jam Hwang, Kyu, Lee, Yeong Seon, An, Seong Soo A., Lee, Myung Koo, Joung, Jong Young, No, Kyoung Tai, Lee, Jeongmin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598813/
https://ncbi.nlm.nih.gov/pubmed/26449325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14944
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