The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene

Exposure to the ubiquitous environmental contaminant trichloroethylene (TCE) is associated with cancer and non-cancer toxicity in both humans and rodents. Peroxisome proliferator-activated receptor-alpha (PPARα) is thought to be playing a role in liver toxicity in rodents through activation of the r...

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Vydáno v:Toxicol Sci
Hlavní autoři: Yoo, Hong Sik, Cichocki, Joseph A., Kim, Sungkyoon, Venkatratnam, Abhishek, Iwata, Yasuhiro, Kosyk, Oksana, Bodnar, Wanda, Sweet, Stephen, Knap, Anthony, Wade, Terry, Campbell, Jerry, Clewell, Harvey J., Melnyk, Stepan B., Chiu, Weihsueh A., Rusyn, Ivan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
PPAR-Alpha and TCE Toxicity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598794/
https://ncbi.nlm.nih.gov/pubmed/26136231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv134
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