The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene

Exposure to the ubiquitous environmental contaminant trichloroethylene (TCE) is associated with cancer and non-cancer toxicity in both humans and rodents. Peroxisome proliferator-activated receptor-alpha (PPARα) is thought to be playing a role in liver toxicity in rodents through activation of the r...

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Bibliographic Details
Published in:Toxicol Sci
Main Authors: Yoo, Hong Sik, Cichocki, Joseph A., Kim, Sungkyoon, Venkatratnam, Abhishek, Iwata, Yasuhiro, Kosyk, Oksana, Bodnar, Wanda, Sweet, Stephen, Knap, Anthony, Wade, Terry, Campbell, Jerry, Clewell, Harvey J., Melnyk, Stepan B., Chiu, Weihsueh A., Rusyn, Ivan
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
PPAR-Alpha and TCE Toxicity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598794/
https://ncbi.nlm.nih.gov/pubmed/26136231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv134
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