The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene

Exposure to the ubiquitous environmental contaminant trichloroethylene (TCE) is associated with cancer and non-cancer toxicity in both humans and rodents. Peroxisome proliferator-activated receptor-alpha (PPARα) is thought to be playing a role in liver toxicity in rodents through activation of the r...

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Pubblicato in:Toxicol Sci
Autori principali: Yoo, Hong Sik, Cichocki, Joseph A., Kim, Sungkyoon, Venkatratnam, Abhishek, Iwata, Yasuhiro, Kosyk, Oksana, Bodnar, Wanda, Sweet, Stephen, Knap, Anthony, Wade, Terry, Campbell, Jerry, Clewell, Harvey J., Melnyk, Stepan B., Chiu, Weihsueh A., Rusyn, Ivan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
PPAR-Alpha and TCE Toxicity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598794/
https://ncbi.nlm.nih.gov/pubmed/26136231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv134
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