Loss of Mitochondrial Pyruvate Carrier 2 in Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

Pyruvate transport across the inner mitochondrial membrane is believed to be a prerequisite step for gluconeogenesis in hepatocytes, which is important for maintenance of normoglycemia during prolonged food deprivation, but also contributes to hyperglycemia in diabetes. To determine the requirement...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Metab
Hauptverfasser: McCommis, Kyle S., Chen, Zhouji, Fu, Xiaorong, McDonald, William G., Colca, Jerry R., Kletzien, Rolf F., Burgess, Shawn C., Finck, Brian N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598280/
https://ncbi.nlm.nih.gov/pubmed/26344101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.07.028
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