Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication.

Transcription of type 1 human immunodeficiency virus (HIV-1) provirus is governed by the viral long terminal repeat (LTR). Drugs can block HIV-1 replication by inhibiting activity of its LTR. We report that topotecan, beta-lapachone, and curcumin are potent and selective inhibitors of HIV-1 LTR-dire...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Li, C J, Zhang, L J, Dezube, B J, Crumpacker, C S, Pardee, A B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45975/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8446597/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.5.1839
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