MicroRNA-22 Inhibits Histone Deacetylase 4 to Promote T Helper-17 Cell-Dependent Emphysema

Smoking-related emphysema is a chronic inflammatory disease driven by T helper 17 (T(H)17) cells through molecular mechanisms that remain obscure. Here we have explored the role of microRNA-22 (miR-22) in emphysema. MiR-22 was upregulated in lung myeloid dendritic cells (mDCs) of smokers with emphys...

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Udgivet i:Nat Immunol
Main Authors: Lu, Wen, You, Ran, Yuan, Xiaoyi, Yang, Tianshu, Samuel, Errol L. G., Marcano, Daniela C., Sikkema, William K. A., Tour, James M., Rodriguez, Antony, Kheradmand, Farrah, Corry, David B.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597310/
https://ncbi.nlm.nih.gov/pubmed/26437241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3292
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