Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications

DCLK1 specifically marks colon/pancreatic cancers in mice, and is expressed by human colon adenocarcinomas (hCRCs). Down-regulation of DCLK1 results in loss of cancer-stem-cells (CSCs), and inhibits spheroidal/xenograft growths from hCRC-cells. The 5′-promoter of DCLK1-gene is reportedly hypermethyl...

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Vydáno v:Sci Rep
Hlavní autoři: O’Connell, Malaney R., Sarkar, Shubhashish, Luthra, Gurinder K., Okugawa, Yoshinaga, Toiyama, Yuji, Gajjar, Aakash H., Qiu, Suimin, Goel, Ajay, Singh, Pomila
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597220/
https://ncbi.nlm.nih.gov/pubmed/26447334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14983
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