Hetero-modification of TRAIL trimer for improved drug delivery and in vivo antitumor activities

Poor pharmacokinetics and resistance within some tumor cell lines have been the major obstacles during the preclinical or clinical application of TRAIL (tumor-necrosis-factor (TNF)-related apoptosis-inducing ligand). The half-life of TRAIL(114-281) (114 to 281 amino acids) was revealed to be no more...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Pan, Li-Qiang, Zhao, Wen-Bin, Lai, Jun, Ding, Ding, Wei, Xiao-Yue, Li, Yang-Yang, Liu, Wen-Hui, Yang, Xiao-Yue, Xu, Ying-Chun, Chen, Shu-Qing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597189/
https://ncbi.nlm.nih.gov/pubmed/26445897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14872
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