Improvement of Pharmacokinetic Profile of TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivo

TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) has long been considered a tantalizing target for cancer therapy because it mediates activation of the extrinsic apoptosis pathway in a tumor-specific manner by binding to and trimerizing its functional receptors DR4 or DR5. Despite initial promise...

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Vydáno v:Sci Rep
Hlavní autoři: Liu, Haipeng, Su, Danmei, Zhang, Jinlong, Ge, Shuaishuai, Li, Youwei, Wang, Fei, Gravel, Michel, Roulston, Anne, Song, Qin, Xu, Wei, Liang, Joshua G., Shore, Gordon, Wang, Xiaodong, Liang, Peng
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566391/
https://ncbi.nlm.nih.gov/pubmed/28827692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09518-1
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