Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFRβ Enhances the in vivo Antitumor Effects of Human TRAIL

Human tumor necrosis factor-related apoptosis-inducing ligand (hTRAIL) has exhibited superior in vitro cytotoxicity in a variety of tumor cells. However, hTRAIL showed a disappointing anticancer effect in clinical trials, although hTRAIL-based regimens were well tolerated. One important reason might...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Tao, Ze, Yang, Hao, Shi, Qiuxiao, Fan, Qing, Wan, Lin, Lu, Xiaofeng
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505058/
https://ncbi.nlm.nih.gov/pubmed/28740549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.19091
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