Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme.

Murine interleukin 1 beta (IL-1 beta) convertase (mICE) was identified in cytosolic extracts of peritoneal exudate cells (PECs) and macrophage cell lines. mICE cleaves both the human and mouse IL-1 beta precursors (pIL-1 beta) at sites 1 and 2 but fails to cleave a human pIL-1 beta (Asp116 to Ala) m...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Molineaux, S M, Casano, F J, Rolando, A M, Peterson, E P, Limjuco, G, Chin, J, Griffin, P R, Calaycay, J R, Ding, G J, Yamin, T T
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45969/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8446594/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.5.1809
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