Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme.

Murine interleukin 1 beta (IL-1 beta) convertase (mICE) was identified in cytosolic extracts of peritoneal exudate cells (PECs) and macrophage cell lines. mICE cleaves both the human and mouse IL-1 beta precursors (pIL-1 beta) at sites 1 and 2 but fails to cleave a human pIL-1 beta (Asp116 to Ala) m...

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Main Authors: Molineaux, S M, Casano, F J, Rolando, A M, Peterson, E P, Limjuco, G, Chin, J, Griffin, P R, Calaycay, J R, Ding, G J, Yamin, T T
Format: Artigo
Sprog:Inglês
Udgivet: 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC45969/
https://ncbi.nlm.nih.gov/pubmed/8446594
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