FoxM1 Promotes Stemness and Radio-Resistance of Glioblastoma by Regulating the Master Stem Cell Regulator Sox2

Glioblastoma (GBM) is the most aggressive and most lethal brain tumor. As current standard therapy consisting of surgery and chemo-irradiation provides limited benefit for GBM patients, novel therapeutic options are urgently required. Forkhead box M1 (FoxM1) transcription factor is an oncogenic regu...

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Udgivet i:PLoS One
Main Authors: Lee, Yeri, Kim, Kang Ho, Kim, Dong Geon, Cho, Hee Jin, Kim, Yeonghwan, Rheey, Jinguen, Shin, Kayoung, Seo, Yun Jee, Choi, Yeon-Sook, Lee, Jung-Il, Lee, Jeongwu, Joo, Kyeung Min, Nam, Do-Hyun
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596841/
https://ncbi.nlm.nih.gov/pubmed/26444992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137703
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